UMBREX 50 is a cream with 50% Lipostabilized Pure Urea. It is a keratolytic and exfoliating treatment for localized stubborn cutaneous thickenings that can promote their subsequent mechanical removal. Not greasy, gets quickly absorbed. Its innovative formula also provides a refreshing and emollient effect.
UMBREX 50 contains 50% Pure Lipostabilized Urea.
Urea is an organic compound that when used topically can have moisturizing or keratolytic properties, depending on the concentration of use. The hydrating effect occurs at low concentration owing to the increase in water binding sites in the stratum corneum (SC) and to the reduction of trans-epidermal water loss. The keratoreducing and keratolytic effects occur instead when urea is used at higher concentrations (30-50%). The suggested mechanism seems to be the alteration of the quaternary structure of keratin in the SC through the breakage of hydrogen bonds. Urea is thus able to denature and disperse keratin and reduce the thickness of the SC without damaging the epidermal water barrier.
Apply 1 or 2 times a day on clean and dry affected area. For better and long lasting results, we recommend the use in combination with UMBREX 10.
Cosmetic for external use.
Pan M, Heinecke G, Bernardo S, Tsui C, Levitt J, Urea: a comprehensive review of the clinical literature, Dermatol Online J 2013 Nov 15;19(11):20392 ;
Horii I, Nakayama Y, Obata M, Tagami H. Stratum corneum hydration and amino acid content in xerotic skin. Br. J. Dermatol. 1989 Nov;121(5):587–592. [PMID: 2597631] ;
Y Sasaki, T Tadaki, H Tagami. The effects of a topical application of urea cream on the function of pathological stratum corneum. Acta Dermatol-Kyoto. 1989;84(4):581–586.