Cream

Umbrex 10

15.90 14.31

UMBREX 10 is a cream with 10% Lipostabilized Pure Urea. Provides immediate and prolonged relief to dry, rough and chappy skin. Not greasy, it gets quickly absorbed. It soothes itching, strengthens skin barrier and contributes to smooth, soft and elastic skin.

Features

Dermatological cream with 10% Pure Lipostabilized Urea, 75 ml tube. Italian Parapharmaceutical Code: 974034338.

UMBREX 10 contains 10% Pure Lipostabilized Urea.

Urea is an organic compound that when used topically can have moisturizing or keratolytic properties, depending on the concentration of use. The hydrating effect occurs at low concentration owing to the increase in water binding sites in the stratum corneum (SC) and to the reduction of trans-epidermal water loss. The keratoreducing and keratolytic effects occur instead when urea is used at higher concentrations (30-50%). The suggested mechanism seems to be the alteration of the quaternary structure of keratin in the SC through the breakage of hydrogen bonds. Urea is thus able to denature and disperse keratin and reduce the thickness of the SC without damaging the epidermal water barrier.

Apply regularly in the morning and evening on clean and dry skin. Gently massage until complete absorption.

Cosmetic for external use.

Pan M, Heinecke G, Bernardo S, Tsui C, Levitt J, Urea: a comprehensive review of the clinical literature, Dermatol Online J 2013 Nov 15;19(11):20392 ;

Wilhelm KP, Scholermann A, Bohnsack K et al. Efficacy and tolerability of a topical preparation containing 10% urea in patients with atopic dermatitis. Aktuelle Derm 1998; 24:26–30 ;

Horii I, Nakayama Y, Obata M, Tagami H. Stratum corneum hydration and amino acid content in xerotic skin. Br. J. Dermatol. 1989 Nov;121(5):587–592. [PMID: 2597631];

Y Sasaki, T Tadaki, H Tagami. The effects of a topical application of urea cream on the function of pathological stratum corneum. Acta Dermatol-Kyoto. 1989;84(4):581–586.

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