PODOVAL UR50 Smoothing Keratolytic Treatment is a cream with 50% Lipostabilized Pure Urea useful for severe or persistant callusity, calluses, corns, soft corns, thickened toenails, foot psoriasis. Its keratolytic and exfoliating action can facilitate the subsequent mechanical removal of cutaneous thickenings of feet. Not greasy, gets quickly absorbed. Its innovative formula also provides a refreshing and emollient effect.
Podoval UR50 contains 50% Pure Lipostabilized Urea.
Urea is an organic compound that when used topically can have moisturizing or keratolytic properties, depending on the concentration of use. The hydrating effect occurs at low concentration owing to the increase in water binding sites in the stratum corneum (SC) and to the reduction of trans-epidermal water loss. The keratoreducing and keratolytic effects occur instead when urea is used at higher concentrations (30-50%). The suggested mechanism seems to be the alteration of the quaternary structure of keratin in the SC through the breakage of hydrogen bonds. Urea is thus able to denature and disperse keratin and reduce the thickness of the SC without damaging the epidermal water barrier.
Apply 1 or 2 times a day on clean and dry affected area. For better and long lasting results, we recommend the use in combination with PODOVAL UR10 HYDRATING cream.
Cosmetic for external use.
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Y Sasaki, T Tadaki, H Tagami. The effects of a topical application of urea cream on the function of pathological stratum corneum. Acta Dermatol-Kyoto. 1989;84(4):581–586.